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Interferon alfa-n3 – Verucozitati Genitale sau Veneriene
Interferon alfa-n3 Actiune terapeutica: Antineoplazic Categorie de risc pentru sarcina: C MOD DE ACTIUNE
Se leaga de receptorii aflati pe suprafata celulelor, inhibând astfel replicarea virala, suprimând proliferarea celulara. De asemenea, prezinta efect imunomodulator exprimat prin fagocitarea realizata de macrofage, citotoxicitate limfocitara si cresterea exprimarii antigenelor leucocitare. Dupa administrarea intralezionala, nivelele serice ale interferonului alfa-n3 sunt nedetectabile
INDICATII
Tratamentul intralezional al verucozitatilor genitale sau veneriene determinate de Condylomata acuminata la pacientii cu vârsta peste 18 ani.
CONTRAINDICATII
Hipersensibilitate la interferon alfa. Alergia la IgG, proteinele din ou, neomicina. Lactatia. La pacientii sub 18 ani.
PRECAUTII
Datorita febrei si simptomelor pseudogripale induse de terapie, se recomanda utilizarea cu prudenta la pacientii cu tulburari psihice, angina instabila, IC decompensata, BPOC, DZ si cetoacidoza, tromboflebita, embolism pulmonar, hemofilie, mielosupresie severa, convulsii. Medicamentul trebuie folosit cu prudenta la barbatii fertili. Deoarece medicamentul este produs din sânge uman, exista riscul de transmitere a unor infectii. Eficacitatea administrarii interferonului la pacientii sub 18 ani nu a fost dovedita.
0,05 mL (250000 UI)/verucozitate de 2 ori/saptamâna, 8 saptamâni. Efectul maxim se obtine la o doza de 0,5 mL (2,5M UI). Nu s-a demonstrat eficacitatea unei a doua reprize de terapie.
OBSERVATII PENTRU PACIENT – FAMILIE
Tratamentul intralezional dureaza 8 saptamâni. Leziunile genitale pot disparea în timpul terapiei sau dupa încheierea acesteia. Daca nu apar alte leziuni, este necesara o pauza de 3 luni. Trebuie sa aveti contacte sexuale protejate. Anuntati medicul daca apar reactii de hipersensibilizare (ex. urticarie, hipotensiune, wheezing, reactie anafilactica).
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